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BayGenomics is a consortium of research groups in the San Francisco Bay Area funded as part of NHLBI's Programs for Genomic Applications (grant U01 HL66621). The major goal of BayGenomics is to identify genes
relevant to cardiovascular and pulmonary disease. We are using gene-trap vectors to inactivate thousands of genes in mouse embryonic stem (ES) cells for the purpose of generating knockout mice. We make all of our ES cell lines readily available to the scientific research community.
To date, we have trapped hundreds of mouse genes, many corresponding to novel genes or expressed sequence tags (ESTs). Many of these insertional mutants have already been transmitted through the germline. Many research labs have had success in generating knockout mice from our library of ES cell mutants. For more information, see this gene-trap overview at the Sanger Center.
Each ES cell line in our resource is automatically incorporated into the searchable BayGenomics Database. In addition, to determine whether your own "gene of interest" has been trapped by BayGenomics, you can BLAST your sequence against the BayGenomics Database. BayGenomics cell lines are available for a nominal charge to the scientific research community upon request.
Support for the bioinformatics activities of BayGenomics also comes from the NIH National Center for Research Resources (grant P41 RR01081).
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